REPOSITÓRIO INSTITUCIONAL DA UNIVERSIDADE ESTADUAL DE MARINGÁ (RI-UEM)
A missão do Repositório Institucional da Universidade Estadual de Maringá (RI-UEM) é reunir, preservar e permitir o acesso à memória institucional (científica, técnica, artística e administrativa) da Universidade Estadual de Maringá em formato digital.
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http://repositorio.uem.br:8080/jspui/handle/1/1987| Autor(es): | Takaki, Ione |
| Orientador: | Roberto Kenji Nakamura Cuman |
| Título: | Reações adversas decorrentes da terapia antirretroviral de alta potência em pacientes HIV/AIDS tratados no ambulatório DST/AIDS de Maringá |
| Título(s) alternativo(s): | Adverse drug reaction in hiv- infected people treated with haart in Maringá, southern Brazil |
| Banca: | Francisco Pereria da Silva - UEL |
| Banca: | Roberto Barboza Bazotte - UEM |
| Banca: | Silvana Martins Caparroz Assef - UEM |
| Banca: | Udelysses Janete Veltrini - UNINGÁ |
| Palavras-chave: | AIDS (doença);Saúde pública;Tratamento;HAART (Terapia antirretroviral de alta-atividade);TARV;Adverse drug reaction;Maringá;Paraná (Estado);Brasil.;HIV;AIDS;HAART;Adverse drug reaction;Maringá;Paraná (State);Brazil. |
| Data do documento: | 2016 |
| Editor: | Universidade Estadual de Maringá |
| Resumo: | : Prolonged treatment of HIV-1 disease with highly antiretroviral therapy (HAART) can be difficult to sustain because of adverse drug reactions (ADR). Knowledge of ADR of antiretroviral agents is a critical component of HIV/AIDS care and treatment. A retrospective and prospective analysis of the laboratory and clinicalepidemiological characteristics on chart review was conducted among HIV-infected patients treated with HAART between January 2010 and December 2013, from a public health Center for care and treatment in Maringa, Southern Brazil. The mean age of ART participants was 44.3 ± 10.8 years and males and females have no age difference. The percentage of married participants were 84 (38.2%), of which 39 (46.4%) are females and 45 (53.6%) are males. Immunological and virological profile of participants was evaluated, where the mean of the first and the last CD4+ T count were 550 ± 309 cells/μL and 642 ± 372 cells/μL, respectively. Similarly, the mean viral load was 14,476 ± 58,067 copies/mL and 20,828 ± 106,028 copies/mL. The average time of ARV use is 5.6 ± 4.2 years for all participants in this study. 28 (12.8%) participants reported having failed on adherence to medication for a period during the four years of the study. 102 patients used the therapeutic scheme based in 2 nucleoside reverse transcriptase inhibitors (NRTI) and 1 protease inhibitor (PI), wherein the ARV combination has been used lamivudine (3TC) - zidovidine (AZT) - lopinavir/ritonavir (LPV/r) (31.4%), followed by the ARV combination, 3TC-AZT- atazanavir/ritonavir (ATV/r) (28.4%). The therapeutic scheme 2 NRTI and 1 nonnucleoside reverse transcriptase inhibitors (NNRTI) was used for 79 patients, with the ARV combination was 3TC-AZT- efavirenz (EFZ) (65.8%). Gastrointestinal disorders (25.9%), neuropychiatric symptoms (18.2%) and hypertension (25.4%) are the changes more often presented by patients during the study period. ADRs that presented a greater number of participants were: anemia (48.8%), hypertriglyceridemia (47.3%), hypercholesterolemia (36.1%) and hyperglycemia (22.6%). 38 (17.3%) participants had opportunistic disease and lipodystrophia was observed in 11 (5.0%). The study demonstrated ADRs in HIV-infected patients treat in a public health Center for care and treatment in Maringa. Southern Brazil. |
| Abstract: | |
| URI: | http://repositorio.uem.br:8080/jspui/handle/1/1987 |
| Aparece nas coleções: | 3.3 Tese - Ciências da Saúde (CCS) |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 000223639.pdf | 695,41 kB | Adobe PDF | Visualizar/Abrir |
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