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  3. 3.3 Tese - Ciências da Saúde (CCS)
Use este identificador para citar ou linkar para este item: http://repositorio.uem.br:8080/jspui/handle/1/1987
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.advisorRoberto Kenji Nakamura Cumanpt_BR
dc.contributor.authorTakaki, Ionept_BR
dc.date.accessioned2018-04-09T17:17:24Z-
dc.date.available2018-04-09T17:17:24Z-
dc.date.issued2016pt_BR
dc.identifier.urihttp://repositorio.uem.br:8080/jspui/handle/1/1987-
dc.description.abstracten
dc.languageporpt_BR
dc.publisherUniversidade Estadual de Maringápt_BR
dc.rightsopenAccesspt_BR
dc.subjectAIDS (doença)pt_BR
dc.subjectSaúde públicapt_BR
dc.subjectTratamentopt_BR
dc.subjectHAART (Terapia antirretroviral de alta-atividade)pt_BR
dc.subjectTARVpt_BR
dc.subjectAdverse drug reactionpt_BR
dc.subjectMaringápt_BR
dc.subjectParaná (Estado)pt_BR
dc.subjectBrasil.pt_BR
dc.subjectHIVen
dc.subjectAIDSen
dc.subjectHAARTen
dc.subjectAdverse drug reactionen
dc.subjectMaringáen
dc.subjectParaná (State)en
dc.subjectBrazil.en
dc.titleReações adversas decorrentes da terapia antirretroviral de alta potência em pacientes HIV/AIDS tratados no ambulatório DST/AIDS de Maringápt_BR
dc.title.alternativeAdverse drug reaction in hiv- infected people treated with haart in Maringá, southern Brazilen
dc.typedoctoralThesispt_BR
dc.contributor.referee1Francisco Pereria da Silva - UEL
dc.contributor.referee2Roberto Barboza Bazotte - UEM
dc.contributor.referee3Silvana Martins Caparroz Assef - UEM
dc.contributor.referee4Udelysses Janete Veltrini - UNINGÁ
dc.description.resumo: Prolonged treatment of HIV-1 disease with highly antiretroviral therapy (HAART) can be difficult to sustain because of adverse drug reactions (ADR). Knowledge of ADR of antiretroviral agents is a critical component of HIV/AIDS care and treatment. A retrospective and prospective analysis of the laboratory and clinicalepidemiological characteristics on chart review was conducted among HIV-infected patients treated with HAART between January 2010 and December 2013, from a public health Center for care and treatment in Maringa, Southern Brazil. The mean age of ART participants was 44.3 ± 10.8 years and males and females have no age difference. The percentage of married participants were 84 (38.2%), of which 39 (46.4%) are females and 45 (53.6%) are males. Immunological and virological profile of participants was evaluated, where the mean of the first and the last CD4+ T count were 550 ± 309 cells/μL and 642 ± 372 cells/μL, respectively. Similarly, the mean viral load was 14,476 ± 58,067 copies/mL and 20,828 ± 106,028 copies/mL. The average time of ARV use is 5.6 ± 4.2 years for all participants in this study. 28 (12.8%) participants reported having failed on adherence to medication for a period during the four years of the study. 102 patients used the therapeutic scheme based in 2 nucleoside reverse transcriptase inhibitors (NRTI) and 1 protease inhibitor (PI), wherein the ARV combination has been used lamivudine (3TC) - zidovidine (AZT) - lopinavir/ritonavir (LPV/r) (31.4%), followed by the ARV combination, 3TC-AZT- atazanavir/ritonavir (ATV/r) (28.4%). The therapeutic scheme 2 NRTI and 1 nonnucleoside reverse transcriptase inhibitors (NNRTI) was used for 79 patients, with the ARV combination was 3TC-AZT- efavirenz (EFZ) (65.8%). Gastrointestinal disorders (25.9%), neuropychiatric symptoms (18.2%) and hypertension (25.4%) are the changes more often presented by patients during the study period. ADRs that presented a greater number of participants were: anemia (48.8%), hypertriglyceridemia (47.3%), hypercholesterolemia (36.1%) and hyperglycemia (22.6%). 38 (17.3%) participants had opportunistic disease and lipodystrophia was observed in 11 (5.0%). The study demonstrated ADRs in HIV-infected patients treat in a public health Center for care and treatment in Maringa. Southern Brazil.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.programPrograma de Pós-Graduação em Ciências da Saúdept_BR
dc.publisher.initialsUEMpt_BR
dc.subject.cnpq1Ciências da Saúdept_BR
dc.publisher.localMaringá, PRpt_BR
dc.description.physical48 fpt_BR
dc.subject.cnpq2Medicinapt_BR
dc.publisher.centerCentro de Ciências da Saúdept_BR
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