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http://repositorio.uem.br:8080/jspui/handle/1/1987
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.advisor | Roberto Kenji Nakamura Cuman | pt_BR |
dc.contributor.author | Takaki, Ione | pt_BR |
dc.date.accessioned | 2018-04-09T17:17:24Z | - |
dc.date.available | 2018-04-09T17:17:24Z | - |
dc.date.issued | 2016 | pt_BR |
dc.identifier.uri | http://repositorio.uem.br:8080/jspui/handle/1/1987 | - |
dc.description.abstract | en | |
dc.language | por | pt_BR |
dc.publisher | Universidade Estadual de Maringá | pt_BR |
dc.rights | openAccess | pt_BR |
dc.subject | AIDS (doença) | pt_BR |
dc.subject | Saúde pública | pt_BR |
dc.subject | Tratamento | pt_BR |
dc.subject | HAART (Terapia antirretroviral de alta-atividade) | pt_BR |
dc.subject | TARV | pt_BR |
dc.subject | Adverse drug reaction | pt_BR |
dc.subject | Maringá | pt_BR |
dc.subject | Paraná (Estado) | pt_BR |
dc.subject | Brasil. | pt_BR |
dc.subject | HIV | en |
dc.subject | AIDS | en |
dc.subject | HAART | en |
dc.subject | Adverse drug reaction | en |
dc.subject | Maringá | en |
dc.subject | Paraná (State) | en |
dc.subject | Brazil. | en |
dc.title | Reações adversas decorrentes da terapia antirretroviral de alta potência em pacientes HIV/AIDS tratados no ambulatório DST/AIDS de Maringá | pt_BR |
dc.title.alternative | Adverse drug reaction in hiv- infected people treated with haart in Maringá, southern Brazil | en |
dc.type | doctoralThesis | pt_BR |
dc.contributor.referee1 | Francisco Pereria da Silva - UEL | |
dc.contributor.referee2 | Roberto Barboza Bazotte - UEM | |
dc.contributor.referee3 | Silvana Martins Caparroz Assef - UEM | |
dc.contributor.referee4 | Udelysses Janete Veltrini - UNINGÁ | |
dc.description.resumo | : Prolonged treatment of HIV-1 disease with highly antiretroviral therapy (HAART) can be difficult to sustain because of adverse drug reactions (ADR). Knowledge of ADR of antiretroviral agents is a critical component of HIV/AIDS care and treatment. A retrospective and prospective analysis of the laboratory and clinicalepidemiological characteristics on chart review was conducted among HIV-infected patients treated with HAART between January 2010 and December 2013, from a public health Center for care and treatment in Maringa, Southern Brazil. The mean age of ART participants was 44.3 ± 10.8 years and males and females have no age difference. The percentage of married participants were 84 (38.2%), of which 39 (46.4%) are females and 45 (53.6%) are males. Immunological and virological profile of participants was evaluated, where the mean of the first and the last CD4+ T count were 550 ± 309 cells/μL and 642 ± 372 cells/μL, respectively. Similarly, the mean viral load was 14,476 ± 58,067 copies/mL and 20,828 ± 106,028 copies/mL. The average time of ARV use is 5.6 ± 4.2 years for all participants in this study. 28 (12.8%) participants reported having failed on adherence to medication for a period during the four years of the study. 102 patients used the therapeutic scheme based in 2 nucleoside reverse transcriptase inhibitors (NRTI) and 1 protease inhibitor (PI), wherein the ARV combination has been used lamivudine (3TC) - zidovidine (AZT) - lopinavir/ritonavir (LPV/r) (31.4%), followed by the ARV combination, 3TC-AZT- atazanavir/ritonavir (ATV/r) (28.4%). The therapeutic scheme 2 NRTI and 1 nonnucleoside reverse transcriptase inhibitors (NNRTI) was used for 79 patients, with the ARV combination was 3TC-AZT- efavirenz (EFZ) (65.8%). Gastrointestinal disorders (25.9%), neuropychiatric symptoms (18.2%) and hypertension (25.4%) are the changes more often presented by patients during the study period. ADRs that presented a greater number of participants were: anemia (48.8%), hypertriglyceridemia (47.3%), hypercholesterolemia (36.1%) and hyperglycemia (22.6%). 38 (17.3%) participants had opportunistic disease and lipodystrophia was observed in 11 (5.0%). The study demonstrated ADRs in HIV-infected patients treat in a public health Center for care and treatment in Maringa. Southern Brazil. | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.program | Programa de Pós-Graduação em Ciências da Saúde | pt_BR |
dc.publisher.initials | UEM | pt_BR |
dc.subject.cnpq1 | Ciências da Saúde | pt_BR |
dc.publisher.local | Maringá, PR | pt_BR |
dc.description.physical | 48 f | pt_BR |
dc.subject.cnpq2 | Medicina | pt_BR |
dc.publisher.center | Centro de Ciências da Saúde | pt_BR |
Aparece nas coleções: | 3.3 Tese - Ciências da Saúde (CCS) |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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000223639.pdf | 695,41 kB | Adobe PDF | Visualizar/Abrir |
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