Efeito do ácido cinâmico sobre a resposta inflamatória aguda

Abstract

Over the years, many studies have appeared in the literature, focusing particularly on the medicinal application of cinnamic acid, such as anticancer activity, tuberculosis, atimalária, antifungal, antimicrobial, anti-atherogenic and anti-oxidant. But few studies have shown a potential anti-inflammatory activity of this compound in animal models. Thus, objective of this study was to evaluate the anti-inflammatory activity of cinnamic acid in experimental models of acute inflammation, such as ear edema induced by croton oil, paw edema induced by carrageenan or dextran and leukocyte chemotaxis in vitro. They also assessed the activity of the enzyme myeloperoxidase (MPO) and the concentration of nitric oxide (NO) in the section of the ears and the plantar tissue. The cinnamic acid, the bromide test of 3- (4,5-Dimetoltiazol-2-yl) -2,5- diphenyltetrazolium bromide (MTT) showed low cytotoxicity and showed no activity when used as a chemotactic agent in vitro in two concentrations and 15 μg/mL; But the concentration of 150 μg/mL a significant chemotactic activity was observed, proving to be a chemotactic agent in higher concentration. The effect antiedematogenic topic (ear edema) was observed at a concentration of 5.0 mg/ear, while the systemic (paw edema) at all doses tested. The cinnamic acid inhibited leukocyte infiltration as assessed by reduction in MPO activity and reduced levels of NO in inflamed tissue. The results indicate that the cinnamic acid has an anti-inflammatory activity as demonstrated by inhibition of edema formation and leukocyte infiltration reduction.