Prevalência do Torque Teno Vírus (TTV) em doadores saudáveis das regiões norte e noroeste paranaense

Abstract

Torque Teno Vírus (TTV) is a recently discovered virus in the periphery blood of Japanese-stock patients diagnosed with post-transfusion hepatitis, with high alanine aminotranspherase levels (ALT). TTV is associated with several pathologies and occurs in apparently healthy people. High predominance levels of infection by TTV may be found in different regions of the world and its transmission may occur through different modes. Current research detected TTV predominance in healthy donors living in the northern and northwestern regions of the state of Paraná, Brazil, in 2010, and verified by DNA samples from bone marrow volunteer donors through nested Polymerase Chain Reaction with a set of oligoinitiators for the N22 region. Virus has been detected in 69% (380/551) of healthy donors, with significant prevalence (74.7%; 124-551) within the 18 - 24-year-old bracket and in 70% (144/206) males and 68.4% (236/345) females. No significant association existed between the TTV and the variables ethnic group and civil state (p>0.05). The proportion of healthy donors but virus carriers did not differ with regard to the regions under analysis. TTV in apparently healthy individuals may be a risk factor for the development of diseases. Further studies in different healthy populations are required to discover transmission modes and its participation in different pathologies.